Compound Profiles
Evidence ratings assigned per use case — because a compound can have strong data for one application and weak data for another.
BPC-157
T2: Emerging EvidenceBody Protection Compound-157
Joint Pain & RecoverySynthetic peptide derived from human gastric juice. Extensive positive animal data for tendon, ligament and gut healing. No large-scale human trials.
View profile →Semaglutide
T1: Strong EvidenceGLP-1 Receptor Agonist
Weight ManagementFDA-approved for weight management and type 2 diabetes. Robust clinical trial data. Compounded versions face an evolving regulatory landscape.
View profile →CJC-1295 / Ipamorelin
T2: Emerging EvidenceGrowth Hormone Secretagogue Combination
Muscle & Athletic PerformanceGrowth hormone secretagogue combination with synergistic effects. Documented human data for GH elevation. Furthest along in FDA reclassification.
View profile →TB-500
T2: Emerging EvidenceThymosin Beta-4 (synthetic fragment)
Joint Pain & RecoverySynthetic Thymosin Beta-4. Frequently combined with BPC-157 for tissue repair through complementary mechanisms. Strongest human data is in ophthalmic applications.
View profile →Thymosin Alpha-1
T1: Strong EvidenceTα1 / Zadaxin (Immune Modulator)
Immune & Gut HealthApproved as Zadaxin in 35+ countries for hepatitis B and C. The strongest evidence base of any Category 2 peptide — 30+ trials, 11,000+ subjects. Frequently combined with BPC-157 for gut-focused immune support.
View profile →Semax
T2: Emerging EvidenceACTH 4–10 Analog (Cognitive Nasal Peptide)
Cognitive PerformanceRussian-approved cognitive nasal peptide that modulates dopamine/serotonin and upregulates BDNF. The strongest evidence-to-risk ratio in the cognitive category, with the caveat that most research is in Russian.
View profile →Selank
T2: Emerging EvidenceTuftsin Analog (Anxiolytic Nasal Peptide)
Cognitive PerformanceNasal anxiolytic that modulates GABA without sedation, dependency, or tolerance. PCAC-referred September 2024 — further along in U.S. reclassification than Semax. Frequently paired with Semax.
View profile →Dihexa
T3: Early / AnecdotalSynthetic Hexapeptide (HGF/c-Met activator)
Cognitive PerformanceThe most hyped and least proven cognitive peptide. Foundational research has been retracted, no human trials exist, and the “millions of times more potent than BDNF” claim traces back to compromised work. We cannot recommend it.
View profile →PE-22-28
T3: Early / AnecdotalSpadin Analog (TREK-1 Channel Inhibitor)
Cognitive PerformanceEarly-stage spadin analog targeting TREK-1 channels for mood and cognition. Almost entirely preclinical with minimal published data. Included for completeness.
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