Compound Profiles

Evidence ratings assigned per use case — because a compound can have strong data for one application and weak data for another.

BPC-157

T2: Emerging Evidence

Body Protection Compound-157

Joint Pain & Recovery

Synthetic peptide derived from human gastric juice. Extensive positive animal data for tendon, ligament and gut healing. No large-scale human trials.

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Semaglutide

T1: Strong Evidence

GLP-1 Receptor Agonist

Weight Management

FDA-approved for weight management and type 2 diabetes. Robust clinical trial data. Compounded versions face an evolving regulatory landscape.

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CJC-1295 / Ipamorelin

T2: Emerging Evidence

Growth Hormone Secretagogue Combination

Muscle & Athletic Performance

Growth hormone secretagogue combination with synergistic effects. Documented human data for GH elevation. Furthest along in FDA reclassification.

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TB-500

T2: Emerging Evidence

Thymosin Beta-4 (synthetic fragment)

Joint Pain & Recovery

Synthetic Thymosin Beta-4. Frequently combined with BPC-157 for tissue repair through complementary mechanisms. Strongest human data is in ophthalmic applications.

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Thymosin Alpha-1

T1: Strong Evidence

Tα1 / Zadaxin (Immune Modulator)

Immune & Gut Health

Approved as Zadaxin in 35+ countries for hepatitis B and C. The strongest evidence base of any Category 2 peptide — 30+ trials, 11,000+ subjects. Frequently combined with BPC-157 for gut-focused immune support.

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Semax

T2: Emerging Evidence

ACTH 4–10 Analog (Cognitive Nasal Peptide)

Cognitive Performance

Russian-approved cognitive nasal peptide that modulates dopamine/serotonin and upregulates BDNF. The strongest evidence-to-risk ratio in the cognitive category, with the caveat that most research is in Russian.

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Selank

T2: Emerging Evidence

Tuftsin Analog (Anxiolytic Nasal Peptide)

Cognitive Performance

Nasal anxiolytic that modulates GABA without sedation, dependency, or tolerance. PCAC-referred September 2024 — further along in U.S. reclassification than Semax. Frequently paired with Semax.

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Dihexa

T3: Early / Anecdotal

Synthetic Hexapeptide (HGF/c-Met activator)

Cognitive Performance

The most hyped and least proven cognitive peptide. Foundational research has been retracted, no human trials exist, and the “millions of times more potent than BDNF” claim traces back to compromised work. We cannot recommend it.

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PE-22-28

T3: Early / Anecdotal

Spadin Analog (TREK-1 Channel Inhibitor)

Cognitive Performance

Early-stage spadin analog targeting TREK-1 channels for mood and cognition. Almost entirely preclinical with minimal published data. Included for completeness.

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